Makoto Higuchi Selected Research

(E,E)- 1- bromo- 2,5- bis(3- hydroxycarbonyl- 4- hydroxy)styrylbenzene- alpha alpha'-(13)C(2)

7/2004

Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques.

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Makoto Higuchi Research Topics

Disease

63	Alzheimer Disease (Alzheimer's Disease) 01/2024 - 07/2004
28	Tauopathies 01/2024 - 07/2002
20	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2023 - 04/2003
20	Neuroinflammatory Diseases 01/2023 - 02/2007
18	Cognitive Dysfunction 01/2020 - 03/2002
13	Atrophy 12/2023 - 11/2006
13	Dementia (Dementias) 12/2020 - 06/2008
11	Inflammation (Inflammations) 10/2023 - 02/2009
9	Amyloid Plaque 06/2020 - 07/2004
8	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2023 - 02/2010
6	Mental Disorders (Mental Disorder) 01/2024 - 09/2008
6	Brain Ischemia (Cerebral Ischemia) 01/2023 - 04/2015
6	Amyloidosis 01/2016 - 04/2005
6	Polypoidal Choroidal Vasculopathy 09/2014 - 11/2010
5	Schizophrenia (Dementia Praecox) 01/2023 - 05/2006
5	Gliosis 10/2021 - 02/2006
5	Parkinson Disease (Parkinson's Disease) 02/2017 - 12/2005
4	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2024 - 10/2016
4	Frontotemporal Dementia (Semantic Dementia) 01/2024 - 05/2004
4	Multiple System Atrophy 10/2022 - 01/2017
4	Disease Progression 12/2019 - 01/2003
4	Parkinsonian Disorders (Parkinsonism) 12/2019 - 01/2017
3	Corticobasal Degeneration 01/2022 - 09/2013
3	Ischemia 04/2016 - 10/2013
3	Nephritis 12/2012 - 06/2005
3	Nephrotic Syndrome (Syndrome, Nephrotic) 12/2012 - 12/2002
3	Retinal Perforations 06/2012 - 02/2008
3	Glomerulonephritis 01/2007 - 01/2003
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2024 - 01/2019
2	Ischemic Stroke 01/2023 - 04/2015
2	Epilepsy (Aura) 01/2022 - 01/2020
2	Brain Diseases (Brain Disorder) 01/2022 - 01/2016
2	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022 - 01/2017
2	Infarction (Infarctions) 01/2022 - 01/2015
2	Stroke (Strokes) 01/2021 - 02/2006
2	Proteostasis Deficiencies 01/2021 - 12/2020
2	Lewy Body Disease (Lewy Body Dementia) 01/2017 - 02/2013
2	Overactive Urinary Bladder (Overactive Bladder) 10/2014 - 01/2013
2	Vomiting 10/2014 - 04/2007
2	Diabetic Nephropathies (Diabetic Nephropathy) 12/2012 - 01/2006
2	Proteinuria 12/2012 - 05/2011
2	Vitreous Detachment (Posterior Vitreous Detachment) 06/2012 - 09/2011
2	Epiretinal Membrane (Epiretinal Membranes) 06/2012 - 04/2009
2	Retinal Detachment (Retinal Detachments) 09/2011 - 04/2008
2	Wounds and Injuries (Trauma) 05/2011 - 10/2005
2	Kidney Diseases (Kidney Disease) 05/2011 - 05/2011

Drug/Important Bio-Agent (IBA)

36	Amyloid (Amyloid Fibrils)IBA 01/2024 - 04/2003
28	Proteins (Proteins, Gene)FDA Link 12/2023 - 12/2002
21	Biomarkers (Surrogate Marker)IBA 01/2024 - 04/2005
19	LigandsIBA 05/2023 - 02/2006
16	tau Proteins (tau Protein)IBA 01/2024 - 10/2006
16	Amyloid beta-PeptidesIBA 07/2023 - 04/2005
10	Peptides (Polypeptides)IBA 07/2016 - 11/2005
9	GABA-A Receptors (GABA(A) Receptor)IBA 07/2012 - 02/2006
5	N,N- diethyl- 2- (2- (4- (2- fluoroethoxy)phenyl)- 5,7- dimethylpyrazolo(1,5- a)pyrimidin- 3- yl)acetamideIBA 01/2023 - 01/2016
5	Ranibizumab (Lucentis)FDA Link 09/2014 - 11/2010
5	DAA 1106IBA 07/2012 - 09/2007
4	Glutamic Acid (Glutamate)FDA Link 01/2023 - 02/2009
4	SynucleinsIBA 10/2022 - 01/2017
4	RNA (Ribonucleic Acid)IBA 01/2021 - 06/2002
4	Protein Isoforms (Isoforms)IBA 01/2017 - 07/2002
4	PK 11195 (PK11195)IBA 04/2016 - 09/2007
3	benzothiazoleIBA 05/2023 - 01/2017
3	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2023 - 04/2015
3	CalciumIBA 03/2021 - 11/2009
3	Complement System Proteins (Complement)IBA 03/2021 - 03/2011
3	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 12/2002
3	AcetylcholinesteraseIBA 01/2018 - 07/2010
3	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2017 - 09/2013
3	CytokinesIBA 09/2013 - 01/2003
3	PPAR alphaIBA 05/2011 - 01/2007
3	Neprilysin (Neutral Endopeptidase)IBA 06/2006 - 04/2005
2	Serotonin (5 Hydroxytryptamine)IBA 01/2024 - 01/2013
2	Antipsychotic Agents (Antipsychotics)IBA 01/2023 - 11/2017
2	Designer DrugsIBA 01/2023 - 01/2022
2	Therapeutic UsesIBA 01/2023 - 01/2003
2	PHA-568487EIBA 01/2023 - 01/2018
2	Essential Amino AcidsIBA 10/2021 - 01/2020
2	Indicators and Reagents (Reagents)IBA 08/2021 - 01/2012
2	Dopamine (Intropin)FDA LinkGeneric 11/2020 - 05/2006
2	Norepinephrine Plasma Membrane Transport Proteins (Norepinephrine Transporter)IBA 11/2020 - 12/2017
2	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2018 - 01/2017
2	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 11/2017 - 05/2006
2	florbetapirIBA 07/2015 - 05/2015
2	pyridineIBA 01/2015 - 10/2014
2	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 10/2014 - 04/2007
2	NADPH Oxidases (NAD(P)H oxidase)IBA 07/2013 - 01/2007
2	calpastatinIBA 03/2012 - 08/2005
2	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 01/2012 - 01/2008
2	Clofibrate FDA Link 01/2012 - 05/2011
2	1-phenyl-3,3-dimethyltriazene (PDT)IBA 05/2011 - 04/2008
2	Indocyanine Green (Cardio-Green)FDA LinkGeneric 11/2010 - 03/2009
2	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 04/2009 - 09/2008

Therapy/Procedure

16	Therapeutics 11/2022 - 07/2002
5	Vitrectomy 06/2012 - 02/2008
4	Injections 02/2014 - 07/2012
3	Lasers (Laser) 02/2014 - 11/2010
3	Renal Dialysis (Hemodialysis) 01/2012 - 12/2003
3	Kidney Transplantation 08/2011 - 06/2005
2	Intravitreal Injections 07/2012 - 11/2010